ONS drug-poisoning registrations in England and Wales fell slightly in 2025. Cocaine became the most frequently mentioned specific substance despite a fall in its own count; opioids remained the largest substance group. Explore the latest evidence on use, deaths, treatment, emerging substances and wastewater. TD Research Lab brings together evidence for England, Scotland, Wales and Northern Ireland, with coverage limits stated, to support public health teams, commissioners and frontline services. Official statistics, experimental estimates and frontline intelligence are labelled separately; each dataset retains its own reporting period.
Editorial review: 4 November 2026
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TD ConsultancySpecialist UK drug and alcohol training, consultancy and evidence-based resources for commissioners and frontline services.
